Burden of allergic diseases in Asia Pacific Allergic rhinitis Allergic rhinitis is a symptomatic condition of the nose caused by allergen exposure and Ig E-mediated inflammation.
More specifically, this was for his discoveries that synthesized agents that inhibited the actions of various body substances, particularly on the vascular and musculoskeletal systems.Another major drawback for some second-generation agents was documentation in the late 1990s of significant cardiotoxicity.Allergic rhinitis is frequently encountered in primary care.Patients report that allergic rhinitis has a marked detrimental effect on their sleep, social life, quality of life, and attendance and functioning at school and work.Bilastine, a novel new-generation antihistamine that is highly selective for the H histamine receptor, has a rapid onset and prolonged duration of action.
This agent does not interact with the cytochrome P450 system and does not undergo significant metabolism in humans, suggesting that it has very low potential for drug–drug interactions, and does not require dose adjustment in renal impairment.
However, the prevalence of allergic rhinitis subtypes does differ between countries in Asia Pacific.
In several Southeast Asian surveys, ~70% of patients with allergic rhinitis had persistent disease and ~30% had intermittent symptoms, The most frequent causes of acute urticaria, which may affect up to 15%–25% of all individuals at some stage in their lives, are viral infections (especially affecting the upper respiratory tract), food allergies, and drug adverse reactions.
Research methodology For the systematic review of bilastine data, a Pub Med search was undertaken of all publications including “bilastine” in the title and/or abstract. All preclinical and clinical trials were assessed for inclusion in the review.
Attention was preferentially given to randomized controlled trials, with appropriate controls for variation and bias (eg, placebo group, blinding).
Figure 1 Intracellular signaling processes mediated by G-proteins after interaction of histamine with each receptor subtype.